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| Year | Award | Ceremony | Nomination | Movie |
|---|
| 2017 | Jupiter Award | Jupiter Award | Best International Actress | Freeheld (2015) |
| 2016 | Jupiter Award | Jupiter Award | Best International Actress | Still Alice (2014) |
| 2016 | Razzie Award | Razzie Awards | Worst Supporting Actress | Seventh Son (2014) |
| 2016 | Movies for Grownups Award | AARP Movies for Grownups Awards | Best Grownup Love Story | Freeheld (2015) |
| 2016 | EDA Special Mention Award | Alliance of Women Film Journalists | Most Egregious Age Difference Between the Leading Man and the Love Interest | Freeheld (2015) |
| 2015 | IOFCP Award | International Online Film Critics' Poll | Best Actress in a Leading Role | Still Alice (2014) |
| 2015 | IOMA | Italian Online Movie Awards (IOMA) | Best Actress (Miglior attrice protagonista) | Still Alice (2014) |
| 2015 | IOMA | Italian Online Movie Awards (IOMA) | Best Supporting Actress (Miglior attrice non protagonista) | Maps to the Stars (2014) |
| 2015 | ALFS Award | London Critics Circle Film Awards | Actress of the Year | Maps to the Stars (2014) |
| 2015 | NCFCA Award | North Carolina Film Critics Association | Best Actress | Still Alice (2014) |
| 2015 | Tar Heel Award | North Carolina Film Critics Association | Still Alice (2014) |
| 2015 | Seattle Film Critics Award | Seattle Film Critics Awards | Best Actress | Still Alice (2014) |
| 2015 | Courage in Acting Award | Women Film Critics Circle Awards | Freeheld (2015) |
| 2015 | Invisible Woman Award | Women Film Critics Circle Awards | Freeheld (2015) |
| 2015 | WFCC Award | Women Film Critics Circle Awards | Best Screen Couple | Freeheld (2015) |
| 2015 | Golden Globe | Golden Globes, USA | Best Performance by an Actress in a Motion Picture - Comedy or Musical | Maps to the Stars (2014) |
| 2015 | Movies for Grownups Award | AARP Movies for Grownups Awards | Best Actress | Maps to the Stars (2014) |
| 2015 | Movies for Grownups Award | AARP Movies for Grownups Awards | Best Grownup Love Story | Still Alice (2014) |
| 2015 | EDA Female Focus Award | Alliance of Women Film Journalists | Actress Defying Age and Agism | Still Alice (2014) |
| 2015 | EDA Special Mention Award | Alliance of Women Film Journalists | Actress Defying Age and Ageism |
| 2015 | Canadian Screen Award | Canadian Screen Awards, CA | Performance by an Actress in a Leading Role | Maps to the Stars (2014) |
| 2015 | Cinema Bloggers Award | Cinema Bloggers Awards, Portugal | Best Supporting Actress - International Competition | Maps to the Stars (2014) |
| 2015 | GFCA Award | Georgia Film Critics Association (GFCA) | Best Actress | Still Alice (2014) |
| 2015 | Gold Derby Award | Gold Derby Awards | Lead Actress | Still Alice (2014) |
| 2014 | ICP Award | Indiewire Critics' Poll | Best Lead Actress | Still Alice (2014) |
| 2014 | OFCS Award | Online Film Critics Society Awards | Best Actress | Still Alice (2014) |
| 2014 | SLFCA Award | St. Louis Film Critics Association, US | Best Actress | Still Alice (2014) |
| 2014 | VVFP Award | Village Voice Film Poll | Best Actress | Still Alice (2014) |
| 2014 | WIN Award | Women's Image Network Awards | Actress Feature Film | Still Alice (2014) |
| 2014 | Movies for Grownups Award | AARP Movies for Grownups Awards | Best Supporting Actress | Don Jon (2013) |
| 2014 | DFCS Award | Detroit Film Critic Society, US | Best Actress | Still Alice (2014) |
| 2014 | Golden Schmoes | Golden Schmoes Awards | Best Actress of the Year | Still Alice (2014) |
| 2013 | DFCC | Dublin Film Critics Circle Awards | Best Actress | What Maisie Knew (2012) |
| 2013 | Fright Meter Award | Fright Meter Awards | Best Supporting Actress | Carrie (2013) |
| 2013 | Dorian Award | Gay and Lesbian Entertainment Critics Association (GALECA) | TV Performance of the Year - Actress | Game Change (2012) |
| 2012 | Jupiter Award | Jupiter Award | Best International Actress | Crazy, Stupid, Love. (2011) |
| 2012 | Golden Nymph | Monte-Carlo TV Festival | Television Films - Best Performance by an Actress | Game Change (2012) |
| 2012 | WIN Award | Women's Image Network Awards | Best Actress in a Made for Television Movie | Game Change (2012) |
| 2011 | Actor | Screen Actors Guild Awards | Outstanding Performance by a Cast in a Motion Picture | The Kids Are All Right (2010) |
| 2011 | Golden Globe | Golden Globes, USA | Best Performance by an Actress in a Motion Picture - Comedy or Musical | The Kids Are All Right (2010) |
| 2011 | BAFTA Film Award | BAFTA Awards | Best Leading Actress | The Kids Are All Right (2010) |
| 2011 | Movies for Grownups Award | AARP Movies for Grownups Awards | Best Actress | The Kids Are All Right (2010) |
| 2011 | EDA Special Mention Award | Alliance of Women Film Journalists | Bravest Performance Award | The Kids Are All Right (2010) |
| 2011 | EDA Female Focus Award | Alliance of Women Film Journalists | Actress Defying Age and Ageism | The Kids Are All Right (2010) |
| 2011 | COFCA Award | Central Ohio Film Critics Association | Best Actress | The Kids Are All Right (2010) |
| 2011 | COFCA Award | Central Ohio Film Critics Association | Best Ensemble | The Kids Are All Right (2010) |
| 2010 | HFCS Award | Houston Film Critics Society Awards | Best Supporting Actress | The Kids Are All Right (2010) |
| 2010 | OFTA Film Award | Online Film & Television Association | Best Supporting Actress | A Single Man (2009) |
| 2010 | OFCS Award | Online Film Critics Society Awards | Best Supporting Actress | A Single Man (2009) |
| 2010 | PFCS Award | Phoenix Film Critics Society Awards | Best Actress in a Leading Role | The Kids Are All Right (2010) |
| 2010 | PFCS Award | Phoenix Film Critics Society Awards | Best Ensemble Acting | The Kids Are All Right (2010) |
| 2010 | Satellite Award | Satellite Awards | Best Actress in a Motion Picture, Comedy or Musical | The Kids Are All Right (2010) |
| 2010 | VVFP Award | Village Voice Film Poll | Best Supporting Actress | The Kids Are All Right (2010) |
| 2010 | WAFCA Award | Washington DC Area Film Critics Association Awards | Best Acting Ensemble | The Kids Are All Right (2010) |
| 2010 | Golden Globe | Golden Globes, USA | Best Performance by an Actress in a Supporting Role in a Motion Picture | A Single Man (2009) |
| 2010 | ACCA | Awards Circuit Community Awards | Best Performance by an Actress in a Leading Role | The Kids Are All Right (2010) |
| 2010 | Critics Choice Award | Broadcast Film Critics Association Awards | Best Supporting Actress | A Single Man (2009) |
| 2010 | Chlotrudis Award | Chlotrudis Awards | Best Supporting Actress | A Single Man (2009) |
| 2010 | DFCS Award | Denver Film Critics Society | Best Supporting Actress | A Single Man (2009) |
| 2010 | Gold Derby Award | Gold Derby Awards | Supporting Actress of the Decade | The Hours (2002) |
| 2010 | Gold Derby Award | Gold Derby Awards | Lead Actress of the Decade | Far from Heaven (2002) |
| 2010 | Gotham Independent Film Award | Gotham Awards | Best Ensemble Performance | The Kids Are All Right (2010) |
| 2009 | VFCC Award | Vancouver Film Critics Circle | Best Actress in a Canadian Film | Blindness (2008) |
| 2009 | VVFP Award | Village Voice Film Poll | Best Supporting Actress | A Single Man (2009) |
| 2009 | WAFCA Award | Washington DC Area Film Critics Association Awards | Best Supporting Actress | A Single Man (2009) |
| 2009 | Saturn Award | Academy of Science Fiction, Fantasy & Horror Films, USA | Best Actress | Blindness (2008) |
| 2009 | CFCA Award | Chicago Film Critics Association Awards | Best Supporting Actress | A Single Man (2009) |
| 2006 | Stinker Award | The Stinkers Bad Movie Awards | Most Annoying Fake Accent: Female | Freedomland (2006) |
| 2006 | TV Land Award | TV Land Awards | Little Screen/Big Screen Star (Women) |
| 2006 | ACCA | Awards Circuit Community Awards | Best Cast Ensemble | Children of Men (2006) |
| 2005 | Jupiter Award | Jupiter Award | Best International Actress | The Forgotten (2004) |
| 2005 | People's Choice Award | People's Choice Awards, USA | Favorite Female Movie Star |
| 2005 | Satellite Award | Satellite Awards | Outstanding Actress in a Motion Picture, Drama | The Prize Winner of Defiance, Ohio (2005) |
| 2005 | Teen Choice Award | Teen Choice Awards | Choice Movie Scary Scene | The Forgotten (2004) |
| 2005 | Saturn Award | Academy of Science Fiction, Fantasy & Horror Films, USA | Best Actress | The Forgotten (2004) |
| 2004 | Empire Award | Empire Awards, UK | Best Actress | Far from Heaven (2002) |
| 2003 | IOMA | Italian Online Movie Awards (IOMA) | Best Actress (Miglior attrice protagonista) | Far from Heaven (2002) |
| 2003 | Grace Award | MovieGuide Awards | Most Inspiring Movie Acting | Far from Heaven (2002) |
| 2003 | PFCS Award | Phoenix Film Critics Society Awards | Best Acting Ensemble | The Hours (2002) |
| 2003 | Golden Satellite Award | Satellite Awards | Best Actress in a Motion Picture, Drama | Far from Heaven (2002) |
| 2003 | Golden Satellite Award | Satellite Awards | Best Actress in a Supporting Role, Drama | The Hours (2002) |
| 2003 | Actor | Screen Actors Guild Awards | Outstanding Performance by a Female Actor in a Leading Role | Far from Heaven (2002) |
| 2003 | Actor | Screen Actors Guild Awards | Outstanding Performance by a Female Actor in a Supporting Role | The Hours (2002) |
| 2003 | Actor | Screen Actors Guild Awards | Outstanding Performance by the Cast of a Theatrical Motion Picture | The Hours (2002) |
| 2003 | Oscar | Academy Awards, USA | Best Actress in a Leading Role | Far from Heaven (2002) |
| 2003 | Oscar | Academy Awards, USA | Best Actress in a Supporting Role | The Hours (2002) |
| 2003 | Golden Globe | Golden Globes, USA | Best Performance by an Actress in a Motion Picture - Drama | Far from Heaven (2002) |
| 2003 | BAFTA Film Award | BAFTA Awards | Best Performance by an Actress in a Supporting Role | The Hours (2002) |
| 2003 | Critics Choice Award | Broadcast Film Critics Association Awards | Best Acting Ensemble | The Hours (2002) |
| 2003 | CFCA Award | Chicago Film Critics Association Awards | Best Supporting Actress | The Hours (2002) |
| 2003 | Chlotrudis Award | Chlotrudis Awards | Best Actress | Far from Heaven (2002) |
| 2003 | Gold Derby Award | Gold Derby Awards | Ensemble Cast | Far from Heaven (2002) |
| 2003 | Gold Derby Award | Gold Derby Awards | Supporting Actress | The Hours (2002) |
| 2002 | Sierra Award | Las Vegas Film Critics Society Awards | Best Actress | Far from Heaven (2002) |
| 2002 | Sierra Award | Las Vegas Film Critics Society Awards | Best Supporting Actress | The Hours (2002) |
| 2002 | Saturn Award | Academy of Science Fiction, Fantasy & Horror Films, USA | Best Actress | Hannibal (2001) |
| 2002 | ACCA | Awards Circuit Community Awards | Best Actress in a Supporting Role | The Hours (2002) |
| 2002 | Golden Schmoes | Golden Schmoes Awards | Best Actress of the Year | Far from Heaven (2002) |
| 2001 | ALFS Award | London Critics Circle Film Awards | Actress of the Year | The End of the Affair (1999) |
| 2001 | MTV Movie Award | MTV Movie Awards | Best Kiss | Hannibal (2001) |
| 2000 | OFTA Film Award | Online Film & Television Association | Best Actress | The End of the Affair (1999) |
| 2000 | OFCS Award | Online Film Critics Society Awards | Best Supporting Actress | Magnolia (1999) |
| 2000 | Golden Satellite Award | Satellite Awards | Best Performance by an Actress in a Motion Picture, Comedy or Musical | An Ideal Husband (1999) |
| 2000 | Actor | Screen Actors Guild Awards | Outstanding Performance by a Female Actor in a Leading Role | The End of the Affair (1999) |
| 2000 | Actor | Screen Actors Guild Awards | Outstanding Performance by a Female Actor in a Supporting Role | Magnolia (1999) |
| 2000 | Actor | Screen Actors Guild Awards | Outstanding Performance by a Cast in a Theatrical Motion Picture | Magnolia (1999) |
| 2000 | Oscar | Academy Awards, USA | Best Actress in a Leading Role | The End of the Affair (1999) |
| 2000 | Golden Globe | Golden Globes, USA | Best Performance by an Actress in a Motion Picture - Drama | The End of the Affair (1999) |
| 2000 | Golden Globe | Golden Globes, USA | Best Performance by an Actress in a Motion Picture - Comedy or Musical | An Ideal Husband (1999) |
| 2000 | BAFTA Film Award | BAFTA Awards | Best Performance by an Actress in a Leading Role | The End of the Affair (1999) |
| 2000 | Blockbuster Entertainment Award | Blockbuster Entertainment Awards | Favorite Supporting Actress - Drama | Magnolia (1999) |
| 2000 | CFCA Award | Chicago Film Critics Association Awards | Best Actress | The End of the Affair (1999) |
| 2000 | CFCA Award | Chicago Film Critics Association Awards | Best Supporting Actress | An Ideal Husband (1999) |
| 2000 | Chlotrudis Award | Chlotrudis Awards | Best Actress | The End of the Affair (1999) |
| 1999 | OFTA Film Award | Online Film & Television Association | Best Ensemble | Cookie's Fortune (1999) |
| 1999 | Golden Satellite Award | Satellite Awards | Best Actress in a Supporting Role in a Motion Picture, Comedy or Musical | The Big Lebowski (1998) |
| 1999 | ACCA | Awards Circuit Community Awards | Best Actress in a Leading Role | The End of the Affair (1999) |
| 1998 | OFTA Film Award | Online Film & Television Association | Best Drama Actress | Boogie Nights (1997) |
| 1998 | OFCS Award | Online Film Critics Society Awards | Best Supporting Actress | The Myth of Fingerprints (1997) |
| 1998 | Actor | Screen Actors Guild Awards | Outstanding Performance by a Female Actor in a Supporting Role | Boogie Nights (1997) |
| 1998 | Actor | Screen Actors Guild Awards | Outstanding Performance by a Cast | Boogie Nights (1997) |
| 1998 | Oscar | Academy Awards, USA | Best Actress in a Supporting Role | Boogie Nights (1997) |
| 1998 | Golden Globe | Golden Globes, USA | Best Performance by an Actress in a Supporting Role in a Motion Picture | Boogie Nights (1997) |
| 1998 | ACCA | Awards Circuit Community Awards | Best Actress in a Supporting Role | The Big Lebowski (1998) |
| 1998 | Blockbuster Entertainment Award | Blockbuster Entertainment Awards | Favorite Actress - Sci-Fi | The Lost World: Jurassic Park (1997) |
| 1998 | CFCA Award | Chicago Film Critics Association Awards | Best Supporting Actress | Boogie Nights (1997) |
| 1998 | Chlotrudis Award | Chlotrudis Awards | Best Supporting Actress | Boogie Nights (1997) |
| 1996 | Independent Spirit Award | Independent Spirit Awards | Best Female Lead | Safe (1995) |
| 1996 | Chlotrudis Award | Chlotrudis Awards | Best Actress | Safe (1995) |
| 1995 | Chlotrudis Award | Chlotrudis Awards | Best Actress | Vanya on 42nd Street (1994) |
| 1994 | Independent Spirit Award | Independent Spirit Awards | Best Supporting Female | Short Cuts (1993) |
| 1993 | Saturn Award | Academy of Science Fiction, Fantasy & Horror Films, USA | Best Supporting Actress | The Hand That Rocks the Cradle (1992) |
| 1989 | Soap Opera Digest Award | Soap Opera Digest Awards | Outstanding Actress in a Supporting Role: Daytime | As the World Turns (1956) |